Nature and Function of Autoantibodies


Antibodies are diagnostic tools in many formats. Antibodies that react with self-molecules and which occurs in healthy human beings  are termed as Natural antibodies or Autoimmunity.Alike antibodies this also provides with the self-defense against infections and diseases and also contribute to the stability of the Immune system. Auto antibodies are those which react with self-antigens. Those antigens are present in specific in organ  such as thyroid gland or all cell types such chromatin, centro-meres. It contains of proteins, nucleic acid, carbohydrates or combination of these. This gives basic information about mechanisms of loss of tolerance and inflammation in patients with autoimmune disorders.


Natural Antibodies are those which binds exogenous antigen such as bacteria, virus and fungi and also binds nucleic acid, serum proteins, which also account for significant amount of Immunoglobulin’s in healthy individual. Since it is produced independently it is Auto antibodies. Depending upon it might be neutral, beneficial, harmful. which display normal affinity and high avidity for self-antigens. Auto antibodies can be detected long before disease onset bio markers help to diagnosis targeting towards therapeutic intervention.

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